Genome of the Komodo dragon reveals adaptations in the cardiovascular and chemosensory systems of monitor lizards
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F19%3A00512006" target="_blank" >RIV/67985904:_____/19:00512006 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11310/19:10409266
Result on the web
<a href="https://www.nature.com/articles/s41559-019-0945-8" target="_blank" >https://www.nature.com/articles/s41559-019-0945-8</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s41559-019-0945-8" target="_blank" >10.1038/s41559-019-0945-8</a>
Alternative languages
Result language
angličtina
Original language name
Genome of the Komodo dragon reveals adaptations in the cardiovascular and chemosensory systems of monitor lizards
Original language description
Monitor lizards are unique among ectothermic reptiles in that they have high aerobic capacity and distinctive cardiovascular physiology resembling that of endothermic mammals. Here, we sequence the genome of the Komodo dragon Varanus komodoensis, the largest extant monitor lizard, and generate a high-resolution de novo chromosome-assigned genome assembly for V. komodoensis using a hybrid approach of long-range sequencing and single-molecule optical mapping. Comparing the genome of V. komodoensis with those of related species, we find evidence of positive selection in pathways related to energy metabolism, cardiovascular homoeostasis, and haemostasis. We also show species-specific expansions of a chemoreceptor gene family related to pheromone and kairomone sensing in V. komodoensis and other lizard lineages. Together, these evolutionary signatures of adaptation reveal the genetic underpinnings of the unique Komodo dragon sensory and cardiovascular systems, and suggest that selective pressure altered haemostasis genes to help Komodo dragons evade the anticoagulant effects of their own saliva. The Komodo dragon genome is an important resource for understanding the biology of monitor lizards and reptiles worldwide.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10603 - Genetics and heredity (medical genetics to be 3)
Result continuities
Project
<a href="/en/project/GJ17-22141Y" target="_blank" >GJ17-22141Y: Evolution of sex chromosomes in toxicoferan reptiles</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Nature Ecology & Evolution
ISSN
2397-334X
e-ISSN
—
Volume of the periodical
3
Issue of the periodical within the volume
8
Country of publishing house
GB - UNITED KINGDOM
Number of pages
12
Pages from-to
1241-1252
UT code for WoS article
000477903700018
EID of the result in the Scopus database
2-s2.0-85069907719