Role of Cyclin-Dependent Kinase 1 in Translational Regulation in the M-Phase

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F20%3A00532022" target="_blank" >RIV/67985904:_____/20:00532022 - isvavai.cz</a>

Result on the web

<a href="https://www.mdpi.com/2073-4409/9/7/1568" target="_blank" >https://www.mdpi.com/2073-4409/9/7/1568</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/cells9071568" target="_blank" >10.3390/cells9071568</a>

Result language

angličtina

Original language name

Role of Cyclin-Dependent Kinase 1 in Translational Regulation in the M-Phase

Original language description

Cyclin dependent kinase 1 (CDK1) has been primarily identified as a key cell cycle regulator in both mitosis and meiosis. Recently, an extramitotic function of CDK1 emerged when evidence was found that CDK1 is involved in many cellular events that are essential for cell proliferation and survival. In this review we summarize the involvement of CDK1 in the initiation and elongation steps of protein synthesis in the cell. During its activation, CDK1 influences the initiation of protein synthesis, promotes the activity of specific translational initiation factors and affects the functioning of a subset of elongation factors. Our review provides insights into gene expression regulation during the transcriptionally silent M-phase and describes quantitative and qualitative translational changes based on the extramitotic role of the cell cycle master regulator CDK1 to optimize temporal synthesis of proteins to sustain the division-related processes: mitosis and cytokinesis.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10601 - Cell biology

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2020

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Cells

ISSN

2073-4409

e-ISSN

—

Volume of the periodical

9

Issue of the periodical within the volume

7

Country of publishing house

CH - SWITZERLAND

Number of pages

14

Pages from-to

1568

UT code for WoS article

000557230500001

EID of the result in the Scopus database

2-s2.0-85087432428