Osteogenic impact of pro-apoptotic caspase inhibitors in MC3T3-E1 cells
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F20%3A00532058" target="_blank" >RIV/67985904:_____/20:00532058 - isvavai.cz</a>
Alternative codes found
RIV/68081715:_____/20:00532058 RIV/00216224:14310/20:00114208 RIV/62157124:16170/20:43878542 RIV/00159816:_____/20:00072992
Result on the web
<a href="https://www.nature.com/articles/s41598-020-64294-9" target="_blank" >https://www.nature.com/articles/s41598-020-64294-9</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s41598-020-64294-9" target="_blank" >10.1038/s41598-020-64294-9</a>
Alternative languages
Result language
angličtina
Original language name
Osteogenic impact of pro-apoptotic caspase inhibitors in MC3T3-E1 cells
Original language description
Caspases are proteases traditionally associated with inflammation and cell death. Recently, they have also been shown to modulate cell proliferation and differentiation. The aim of the current research was to search for osteogenic molecules affected by caspase inhibition and to specify the individual caspases critical for these effects with a focus on proapoptotic caspases: caspase-2, -3, -6, -7, -8 and -9. Along with osteocalcin (Ocn), general caspase inhibition significantly decreased the expression of the Phex gene in differentiated MC3T3-E1 cells. The inhibition of individual caspases indicated that caspase-8 is a major contributor to the modification of Ocn and Phex expression. Caspase-2 and-6 had effects on Ocn and caspase-6 had an effect on Phex. These data confirm and expand the current knowledge about the nonapoptotic roles of caspases and the effect of their pharmacological inhibition on the osteogenic potential of osteoblastic cells.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10605 - Developmental biology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Scientific Reports
ISSN
2045-2322
e-ISSN
—
Volume of the periodical
10
Issue of the periodical within the volume
1
Country of publishing house
GB - UNITED KINGDOM
Number of pages
8
Pages from-to
7489
UT code for WoS article
000560030700035
EID of the result in the Scopus database
2-s2.0-85084236738