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Osteogenic impact of pro-apoptotic caspase inhibitors in MC3T3-E1 cells

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F20%3A00532058" target="_blank" >RIV/67985904:_____/20:00532058 - isvavai.cz</a>

  • Alternative codes found

    RIV/68081715:_____/20:00532058 RIV/00216224:14310/20:00114208 RIV/62157124:16170/20:43878542 RIV/00159816:_____/20:00072992

  • Result on the web

    <a href="https://www.nature.com/articles/s41598-020-64294-9" target="_blank" >https://www.nature.com/articles/s41598-020-64294-9</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1038/s41598-020-64294-9" target="_blank" >10.1038/s41598-020-64294-9</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Osteogenic impact of pro-apoptotic caspase inhibitors in MC3T3-E1 cells

  • Original language description

    Caspases are proteases traditionally associated with inflammation and cell death. Recently, they have also been shown to modulate cell proliferation and differentiation. The aim of the current research was to search for osteogenic molecules affected by caspase inhibition and to specify the individual caspases critical for these effects with a focus on proapoptotic caspases: caspase-2, -3, -6, -7, -8 and -9. Along with osteocalcin (Ocn), general caspase inhibition significantly decreased the expression of the Phex gene in differentiated MC3T3-E1 cells. The inhibition of individual caspases indicated that caspase-8 is a major contributor to the modification of Ocn and Phex expression. Caspase-2 and-6 had effects on Ocn and caspase-6 had an effect on Phex. These data confirm and expand the current knowledge about the nonapoptotic roles of caspases and the effect of their pharmacological inhibition on the osteogenic potential of osteoblastic cells.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10605 - Developmental biology

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2020

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Scientific Reports

  • ISSN

    2045-2322

  • e-ISSN

  • Volume of the periodical

    10

  • Issue of the periodical within the volume

    1

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    8

  • Pages from-to

    7489

  • UT code for WoS article

    000560030700035

  • EID of the result in the Scopus database

    2-s2.0-85084236738