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Innate immunity in Huntington´s disease

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F20%3A00536500" target="_blank" >RIV/67985904:_____/20:00536500 - isvavai.cz</a>

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Innate immunity in Huntington´s disease

  • Original language description

    Huntington's disease (HD) is an inherited progressive neurodegenerative disorder with impairment of motor and cognitive functions. Any preventive or disease-modifying therapies are not available so far. Symptomatic treatment can only affect symptoms and it is not satisfying. Several approaches using RNAi to lower the expression of mutant huntingtin (mHTT) have been developed to date. In order to monitor the success of therapy efficacy in the pre-manifest stages of HD it is important to identify robust biomarkers of the onset and disease progression. The primary pathology of HD results inter alia from massive degeneration of neurons in the basal ganglia and thalamus. However, the expression of mutant huntingtin was detected in all examined tissues. Studies on HD demonstrated altered immune response in HD gene carriers indicating that cytokines may have a significant role in disease development. Therefore, cerebrospinal fluid (CSF) and blood serum may provide insight into pathology of HD, new prospective biomarkers and potential therapeutic targets. Additionally, microglia and monocytes could also serve as possible cellular source of candidate biomarkers to monitor HD progression.

  • Czech name

  • Czech description

Classification

  • Type

    C - Chapter in a specialist book

  • CEP classification

  • OECD FORD branch

    30103 - Neurosciences (including psychophysiology)

Result continuities

  • Project

    <a href="/en/project/LO1609" target="_blank" >LO1609: Models of the Serious Human Diseases: Traumatic Spinal Cord Injury, Huntington’s Disease, Melanoma and Infertility</a><br>

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2020

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Book/collection name

    Translational Research in Serious Human Diseases

  • ISBN

    978-80-200-3158-7

  • Number of pages of the result

    8

  • Pages from-to

    49-56

  • Number of pages of the book

    271

  • Publisher name

    Academia

  • Place of publication

    Praha

  • UT code for WoS chapter