Innate immunity in Huntington´s disease
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F20%3A00536500" target="_blank" >RIV/67985904:_____/20:00536500 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Innate immunity in Huntington´s disease
Original language description
Huntington's disease (HD) is an inherited progressive neurodegenerative disorder with impairment of motor and cognitive functions. Any preventive or disease-modifying therapies are not available so far. Symptomatic treatment can only affect symptoms and it is not satisfying. Several approaches using RNAi to lower the expression of mutant huntingtin (mHTT) have been developed to date. In order to monitor the success of therapy efficacy in the pre-manifest stages of HD it is important to identify robust biomarkers of the onset and disease progression. The primary pathology of HD results inter alia from massive degeneration of neurons in the basal ganglia and thalamus. However, the expression of mutant huntingtin was detected in all examined tissues. Studies on HD demonstrated altered immune response in HD gene carriers indicating that cytokines may have a significant role in disease development. Therefore, cerebrospinal fluid (CSF) and blood serum may provide insight into pathology of HD, new prospective biomarkers and potential therapeutic targets. Additionally, microglia and monocytes could also serve as possible cellular source of candidate biomarkers to monitor HD progression.
Czech name
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Czech description
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Classification
Type
C - Chapter in a specialist book
CEP classification
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OECD FORD branch
30103 - Neurosciences (including psychophysiology)
Result continuities
Project
<a href="/en/project/LO1609" target="_blank" >LO1609: Models of the Serious Human Diseases: Traumatic Spinal Cord Injury, Huntington’s Disease, Melanoma and Infertility</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Book/collection name
Translational Research in Serious Human Diseases
ISBN
978-80-200-3158-7
Number of pages of the result
8
Pages from-to
49-56
Number of pages of the book
271
Publisher name
Academia
Place of publication
Praha
UT code for WoS chapter
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