Revelation of the IFN alpha, IL-10, IL-8 and IL-1 beta as promising biomarkers reflecting immuno-pathological mechanisms in porcine Huntington's disease model

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F16%3A00462030" target="_blank" >RIV/67985904:_____/16:00462030 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1016/j.jneuroim.2016.02.012" target="_blank" >http://dx.doi.org/10.1016/j.jneuroim.2016.02.012</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jneuroim.2016.02.012" target="_blank" >10.1016/j.jneuroim.2016.02.012</a>

Result language

angličtina

Original language name

Revelation of the IFN alpha, IL-10, IL-8 and IL-1 beta as promising biomarkers reflecting immuno-pathological mechanisms in porcine Huntington's disease model

Original language description

Studies on Huntington's disease (HD) demonstrated altered immune response in HD gene carriers. Using multiplexing immunoassay, we simultaneously investigated seven cytokines in secretomes of microglia and blood monocytes, cerebrospinal fluid (CSF) and serum collected from transgenic HD minipigs at pre-symptomatic disease stage. Decline in IFN alpha and IL-10 was observed in CSF and secretome of microglia whilst elevated IL-8 and IL-1 beta levels were secreted by microglia. Additionally, IL-8 was increased in serum. The proportion of mutant huntingtin in microglia may have causative impact on cytokine production. IFN alpha, IL-10, IL-8 and IL-1 beta represent promising biomarkers reflecting immuno-pathological mechanisms in porcine HD model.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FH - Neurology, neuro-surgery, nuero-sciences

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Neuroimmunology

ISSN

0165-5728

e-ISSN

—

Volume of the periodical

293

Issue of the periodical within the volume

2

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

11

Pages from-to

71-81

UT code for WoS article

000374918800012

EID of the result in the Scopus database

2-s2.0-84959345560