Microbiome-gut-brain axis in pathogenesis of neurodegenerative diseases

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F20%3A00536538" target="_blank" >RIV/67985904:_____/20:00536538 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Microbiome-gut-brain axis in pathogenesis of neurodegenerative diseases
Original language description
From the very beginning of our lives, our gut is colonized by a complex of commensal, symbiotic and pathogenic microorganisms. Changes in development and composition of microbial communities can be a potential risk for many diseases, surprisingly including neurodegenerative illnesses. Bidirectional communication between central neural system and gastrointestinal system, called gut-brain axis, plays an important role in this phenomenon. Huntington disease is a hereditary neurodegeneration characterized by motor, cognitive, psychiatric changes, and metabolic dysfunction, e.g. weight loss. This review briefly discusses the gut-brain axis hypothesis and on example of HD gives short overview of possible involvement of gut microbiome in progress of neurodegenerations.
Czech name
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Czech description
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Project
<a href="/en/project/LO1609" target="_blank" >LO1609: Models of the Serious Human Diseases: Traumatic Spinal Cord Injury, Huntington’s Disease, Melanoma and Infertility</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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