A gene copy number arms race in action: X,Y-chromosome transmission distortion across a species barrier
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F23%3A00571306" target="_blank" >RIV/67985904:_____/23:00571306 - isvavai.cz</a>
Alternative codes found
RIV/68081766:_____/23:00571306 RIV/00216224:14310/23:00132105
Result on the web
<a href="https://academic.oup.com/evolut/advance-article/doi/10.1093/evolut/qpad051/7085198" target="_blank" >https://academic.oup.com/evolut/advance-article/doi/10.1093/evolut/qpad051/7085198</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1093/evolut/qpad051" target="_blank" >10.1093/evolut/qpad051</a>
Alternative languages
Result language
angličtina
Original language name
A gene copy number arms race in action: X,Y-chromosome transmission distortion across a species barrier
Original language description
A remarkable gene copy number (CN) arms race system has recently been described in laboratory mice, where Slx, Slxl1 and Sly genes compete over transmission by altering the fertilization success of X and Y chromosome-bearing sperm, respectively. Here, we focus on this system in nature, where natural selection can counter CN/gene product escalation. Our model is house mouse subspecies hybridizing in Europe. In some regions, Y chromosomes of the Eastern subspecies have introgressed onto Western genomic backgrounds, accompanied by sex ratio distortion in favor of males, consistent with the inbred lines suggested mechanism: Overabundance of SLY protein expressed by invading Y chromosomes. We take Slx as representative of the X side of this arms race and measure Slx|Sly CN and expression across an 'Invasion' transect where Ys introgress and a 'Control' transect with negligible introgression. Since we found similar Slx|Sly ratios in both transects, SLY overabundance is unlikely to explain the introgression. However, Slx CN is relatively low in the introgression area, suggesting that Slx is less able to combat Sly effects here. Furthermore, deterministic changes in Slx|Sly expression proportions versus CN proportions suggest standing variation for trans regulation of Slx|Sly is being co-opted in nature where their arms race reduces population fitness.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10602 - Biology (theoretical, mathematical, thermal, cryobiology, biological rhythm), Evolutionary biology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Evolution
ISSN
0014-3820
e-ISSN
1558-5646
Volume of the periodical
77
Issue of the periodical within the volume
6
Country of publishing house
US - UNITED STATES
Number of pages
11
Pages from-to
1330-1340
UT code for WoS article
000963833400001
EID of the result in the Scopus database
2-s2.0-85178302563