Retinal Pigment Epithelium Cell Development: Extrapolating Basic Biology to Stem Cell Research
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F23%3A00572494" target="_blank" >RIV/67985904:_____/23:00572494 - isvavai.cz</a>
Alternative codes found
RIV/68378041:_____/23:00572494 RIV/61389013:_____/23:00572494
Result on the web
<a href="https://www.mdpi.com/2227-9059/11/2/310" target="_blank" >https://www.mdpi.com/2227-9059/11/2/310</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/biomedicines11020310" target="_blank" >10.3390/biomedicines11020310</a>
Alternative languages
Result language
angličtina
Original language name
Retinal Pigment Epithelium Cell Development: Extrapolating Basic Biology to Stem Cell Research
Original language description
The retinal pigment epithelium (RPE) forms an important cellular monolayer, which contributes to the normal physiology of the eye. Damage to the RPE leads to the development of degenerative diseases, such as age-related macular degeneration (AMD). Apart from acting as a physical barrier between the retina and choroidal blood vessels, the RPE is crucial in maintaining photoreceptor (PR) and visual functions. Current clinical intervention to treat early stages of AMD includes stem cell-derived RPE transplantation, which is still in its early stages of evolution. Therefore, it becomes essential to derive RPEs which are functional and exhibit features as observed in native human RPE cells. The conventional strategy is to use the knowledge obtained from developmental studies using various animal models and stem cell-based exploratory studies to understand RPE biogenies and developmental trajectory. This article emphasises such studies and aims to present a comprehensive understanding of the basic biology, including the genetics and molecular pathways of RPE development. It encompasses basic developmental biology and stem cell-based developmental studies to uncover RPE differentiation. Knowledge of the in utero developmental cues provides an inclusive methodology required for deriving RPEs using stem cells.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10601 - Cell biology
Result continuities
Project
<a href="/en/project/TO01000107" target="_blank" >TO01000107: Development of standardized culture, transplantation and banking of RPE cells for treatment of age-related macular degeneration (AMD)</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Biomedicines
ISSN
2227-9059
e-ISSN
2227-9059
Volume of the periodical
11
Issue of the periodical within the volume
2
Country of publishing house
CH - SWITZERLAND
Number of pages
19
Pages from-to
310
UT code for WoS article
000938856800001
EID of the result in the Scopus database
2-s2.0-85148855811