Age-related macular degeneration and modern aspects of therapy
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F20%3A00536563" target="_blank" >RIV/67985904:_____/20:00536563 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Age-related macular degeneration and modern aspects of therapy
Original language description
Age-related macular degeneration (AMD) is a widespread worldwide disease in population over 60 years old. The macula and its retinal pigment epithelial cells (RPE) are influenced by AMD and patients can lose central vision. It can limit reading, driving a car, recognizing faces – living normal life. AMD consists of two types – wet and dry form. The wet form is treatable by injection of anti-VEGF. On the other hand, the dry form is still not treatable and it is subject of research. It includes RPE or stem cell transplantation, macular translocation or gene therapy. The cell transplantation includes injecting suspensions of RPE cells, transplanting RPE cell sheets or inserting membranes with cultivated RPE cells. Primary cells, embryonic stem cells or induced pluripotent stem cells can be used for RPE cell transplantation. Another surgical procedure can be macular translocation, which describes delivering healthy macular mass into an area with healthy RPE cells. But this procedure has been largely abandoned due to poor outcomes. The last described treatment is gene therapy, which can turn the cells of the inner retina into “replacement photoreceptors”.
Czech name
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Czech description
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Classification
Type
C - Chapter in a specialist book
CEP classification
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OECD FORD branch
30207 - Ophthalmology
Result continuities
Project
<a href="/en/project/LO1609" target="_blank" >LO1609: Models of the Serious Human Diseases: Traumatic Spinal Cord Injury, Huntington’s Disease, Melanoma and Infertility</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Book/collection name
Translational Research in Serious Human Diseases
ISBN
978-80-200-3158-7
Number of pages of the result
6
Pages from-to
154-159
Number of pages of the book
271
Publisher name
Academia
Place of publication
Praha
UT code for WoS chapter
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