Plasticity of Dental Cell Types in Development, Regeneration, and Evolution

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F23%3A00573111" target="_blank" >RIV/67985904:_____/23:00573111 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/23:00134154

Result on the web

<a href="https://journals.sagepub.com/doi/10.1177/00220345231154800" target="_blank" >https://journals.sagepub.com/doi/10.1177/00220345231154800</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1177/00220345231154800" target="_blank" >10.1177/00220345231154800</a>

Result language

angličtina

Original language name

Plasticity of Dental Cell Types in Development, Regeneration, and Evolution

Original language description

Recent years have improved our understanding of the plasticity of cell types behind inducing, building, and maintaining different types of teeth. The latest efforts were aided by progress in single-cell transcriptomics, which helped to define not only cell states with mathematical precision but also transitions between them. This includes new aspects of dental epithelial and mesenchymal stem cell niches and beyond. These recent efforts revealed continuous and fluid trajectories connecting cell states during dental development and exposed the natural plasticity of tooth-building progenitors. Such ´developmental´ plasticity seems to be employed for organizing stem cell niches in adult continuously growing teeth. Furthermore, transitions between mature cell types elicited by trauma might represent a replay of embryonic continuous cell states. Alternatively, they could constitute transitions that evolved de novo, not known from the developmental paradigm. In this review, we discuss and exemplify how dental cell types exhibit plasticity during dynamic processes such as development, self-renewal, repair, and dental replacement. Hypothetically, minor plasticity of cell phenotypes and greater plasticity of transitions between cell subtypes might provide a better response to lifetime challenges, such as damage or dental loss. This plasticity might be additionally harnessed by the evolutionary process during the elaboration of dental cell subtypes in different animal lineages. In turn, the diversification of cell subtypes building teeth brings a diversity of their shape, structural properties, and functions.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10605 - Developmental biology

Project

<a href="/en/project/GA23-06160S" target="_blank" >GA23-06160S: Fluctuation of the stem cell niche as a source of tissue adaptability in health and disease</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2023

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Dental Research

ISSN

0022-0345

e-ISSN

1544-0591

Volume of the periodical

102

Issue of the periodical within the volume

6

Country of publishing house

GB - UNITED KINGDOM

Number of pages

10

Pages from-to

589-598

UT code for WoS article

000949948000001

EID of the result in the Scopus database

2-s2.0-85150821602