CHK1-CDC25A-CDK1 regulate cell cycle progression and protect genome integrity in early mouse embryos
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F23%3A00576852" target="_blank" >RIV/67985904:_____/23:00576852 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11310/23:10474055
Result on the web
<a href="https://www.embopress.org/doi/full/10.15252/embr.202256530" target="_blank" >https://www.embopress.org/doi/full/10.15252/embr.202256530</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.15252/embr.202256530" target="_blank" >10.15252/embr.202256530</a>
Alternative languages
Result language
angličtina
Original language name
CHK1-CDC25A-CDK1 regulate cell cycle progression and protect genome integrity in early mouse embryos
Original language description
After fertilization, remodeling of the oocyte and sperm genomes is essential to convert these highly differentiated and transcriptionally quiescent cells into early cleavage-stage blastomeres that are transcriptionally active and totipotent. This developmental transition is accompanied by cell cycle adaptation, such as lengthening or shortening of the gap phases G1 and G2. However, regulation of these cell cycle changes is poorly understood, especially in mammals. Checkpoint kinase 1 (CHK1) is a protein kinase that regulates cell cycle progression in somatic cells. Here, we show that CHK1 regulates cell cycle progression in early mouse embryos by restraining CDK1 kinase activity due to CDC25A phosphatase degradation. CHK1 kinase also ensures the long G2 phase needed for genome activation and reprogramming gene expression in two-cell stage mouse embryos. Finally, Chk1 depletion leads to DNA damage and chromosome segregation errors that result in aneuploidy and infertility.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10605 - Developmental biology
Result continuities
Project
<a href="/en/project/GA20-27742S" target="_blank" >GA20-27742S: Differences in regulation of cell cycle checkpoints between zygote and 2-cell embryo</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Embo Reports
ISSN
1469-221X
e-ISSN
1469-3178
Volume of the periodical
24
Issue of the periodical within the volume
10
Country of publishing house
US - UNITED STATES
Number of pages
22
Pages from-to
e56530
UT code for WoS article
001119180600001
EID of the result in the Scopus database
2-s2.0-85170519683