Extracellular Vesicles as Possible Sources of Huntington’s Disease Biomarkers
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F23%3A00577186" target="_blank" >RIV/67985904:_____/23:00577186 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/23:10477013
Result on the web
<a href="http://dx.doi.org/10.1007/978-3-031-32815-2_3" target="_blank" >http://dx.doi.org/10.1007/978-3-031-32815-2_3</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/978-3-031-32815-2_3" target="_blank" >10.1007/978-3-031-32815-2_3</a>
Alternative languages
Result language
angličtina
Original language name
Extracellular Vesicles as Possible Sources of Huntington’s Disease Biomarkers
Original language description
Extracellular vesicles (EVs) are membrane enveloped particles released from cells to the extracellular environment and body fluids. During their biosynthesis, lipids, proteins, nucleic acids, metabolites and other molecules of the EV producing cell are incorporated into EVs. EVs are able to transfer such molecular cargo to recipient cells and thus participate in intercellular communication. In this chapter, we review the current knowledge about EVs in a rare hereditary neurodegenerative disorder, Huntington’s disease (HD), which is caused by expanded polyglutamine sequence in protein huntingtin. The roles of EVs in HD are presented from several aspects, including the roles of EVs in disease pathogenesis and transfer of mutant huntingtin, EV importance in the search of HD biomarkers with a special focus on proteins and miRNAs, and experimental therapeutic applications of astrocyte- and stem cell-derived EVs as well as engineered EVs in HD.
Czech name
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Czech description
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Classification
Type
C - Chapter in a specialist book
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
<a href="/en/project/GA19-01747S" target="_blank" >GA19-01747S: Proteomic analysis of extracellular vesicles in Huntington's disease</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Book/collection name
Biomarkers for Huntington's Disease
ISBN
978-3-031-32814-5
Number of pages of the result
31
Pages from-to
45-75
Number of pages of the book
475
Publisher name
Springer
Place of publication
Cham
UT code for WoS chapter
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