Enhancing oral squamous cell carcinoma prediction: the prognostic power of the worst pattern of invasion and the limited impact of molecular resection margins
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F23%3A00581026" target="_blank" >RIV/67985904:_____/23:00581026 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14310/23:00133153 RIV/61988987:17110/23:A2402NCN RIV/61989100:27350/23:10253510 RIV/61989100:27640/23:10253510 RIV/00843989:_____/23:E0110577
Result on the web
<a href="https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2023.1287650/full" target="_blank" >https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2023.1287650/full</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3389/fonc.2023.1287650" target="_blank" >10.3389/fonc.2023.1287650</a>
Alternative languages
Result language
angličtina
Original language name
Enhancing oral squamous cell carcinoma prediction: the prognostic power of the worst pattern of invasion and the limited impact of molecular resection margins
Original language description
ObjectiveOral squamous cell carcinoma (OSCC) originates from the mucosal lining of the oral cavity. Almost half of newly diagnosed cases are classified as advanced stage IV disease, which makes resection difficult. In this study, we investigated the pathological features and mutation profiles of tumor margins in OSCC.MethodsWe performed hierarchical clustering of principal components to identify distinct patterns of tumor growth and their association with patient prognosis. We also used next-generation sequencing to analyze somatic mutations in tumor and marginal tissue samples.ResultsOur analyses uncovered that the grade of worst pattern of invasion (WPOI) is strongly associated with depth of invasion and patient survival in multivariable analysis. Mutations were primarily detected in the DNA isolated from tumors, but several mutations were also identified in marginal tissue. In total, we uncovered 29 mutated genes, mainly tumor suppressor genes involved in DNA repair including BRCA genes, however none of these mutations significantly correlated with a higher chance of relapse in our medium-size cohort. Some resection margins that appeared histologically normal harbored tumorigenic mutations in TP53 and CDKN2A genes.ConclusionEven histologically normal margins may contain molecular alterations that are not detectable by conventional histopathological methods, but NCCN classification system still outperforms other methods in the prediction of the probability of disease relapse.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30204 - Oncology
Result continuities
Project
<a href="/en/project/NV19-08-00383" target="_blank" >NV19-08-00383: Prognostic and predictive markers of squamous cell carcinoma invasion in the oral cavity and oropharynx</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Frontiers in Oncology
ISSN
2234-943X
e-ISSN
2234-943X
Volume of the periodical
13
Issue of the periodical within the volume
Dec 22
Country of publishing house
CH - SWITZERLAND
Number of pages
19
Pages from-to
1287650
UT code for WoS article
001136452500001
EID of the result in the Scopus database
2-s2.0-85181688095