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Enhancing oral squamous cell carcinoma prediction: the prognostic power of the worst pattern of invasion and the limited impact of molecular resection margins

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F23%3A00581026" target="_blank" >RIV/67985904:_____/23:00581026 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216224:14310/23:00133153 RIV/61988987:17110/23:A2402NCN RIV/61989100:27350/23:10253510 RIV/61989100:27640/23:10253510 RIV/00843989:_____/23:E0110577

  • Result on the web

    <a href="https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2023.1287650/full" target="_blank" >https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2023.1287650/full</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.3389/fonc.2023.1287650" target="_blank" >10.3389/fonc.2023.1287650</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Enhancing oral squamous cell carcinoma prediction: the prognostic power of the worst pattern of invasion and the limited impact of molecular resection margins

  • Original language description

    ObjectiveOral squamous cell carcinoma (OSCC) originates from the mucosal lining of the oral cavity. Almost half of newly diagnosed cases are classified as advanced stage IV disease, which makes resection difficult. In this study, we investigated the pathological features and mutation profiles of tumor margins in OSCC.MethodsWe performed hierarchical clustering of principal components to identify distinct patterns of tumor growth and their association with patient prognosis. We also used next-generation sequencing to analyze somatic mutations in tumor and marginal tissue samples.ResultsOur analyses uncovered that the grade of worst pattern of invasion (WPOI) is strongly associated with depth of invasion and patient survival in multivariable analysis. Mutations were primarily detected in the DNA isolated from tumors, but several mutations were also identified in marginal tissue. In total, we uncovered 29 mutated genes, mainly tumor suppressor genes involved in DNA repair including BRCA genes, however none of these mutations significantly correlated with a higher chance of relapse in our medium-size cohort. Some resection margins that appeared histologically normal harbored tumorigenic mutations in TP53 and CDKN2A genes.ConclusionEven histologically normal margins may contain molecular alterations that are not detectable by conventional histopathological methods, but NCCN classification system still outperforms other methods in the prediction of the probability of disease relapse.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30204 - Oncology

Result continuities

  • Project

    <a href="/en/project/NV19-08-00383" target="_blank" >NV19-08-00383: Prognostic and predictive markers of squamous cell carcinoma invasion in the oral cavity and oropharynx</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2023

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Frontiers in Oncology

  • ISSN

    2234-943X

  • e-ISSN

    2234-943X

  • Volume of the periodical

    13

  • Issue of the periodical within the volume

    Dec 22

  • Country of publishing house

    CH - SWITZERLAND

  • Number of pages

    19

  • Pages from-to

    1287650

  • UT code for WoS article

    001136452500001

  • EID of the result in the Scopus database

    2-s2.0-85181688095