Retinal venular vessel diameters are smaller during ten days of bed rest
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F23%3A00581564" target="_blank" >RIV/67985904:_____/23:00581564 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14310/23:00133483
Result on the web
<a href="https://www.nature.com/articles/s41598-023-46177-x" target="_blank" >https://www.nature.com/articles/s41598-023-46177-x</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s41598-023-46177-x" target="_blank" >10.1038/s41598-023-46177-x</a>
Alternative languages
Result language
angličtina
Original language name
Retinal venular vessel diameters are smaller during ten days of bed rest
Original language description
Older individuals experience cardiovascular dysfunction during extended bedridden hospital or care home stays. Bed rest is also used as a model to simulate accelerated vascular deconditioning occurring during spaceflight. This study investigates changes in retinal microcirculation during a ten-day bed rest protocol. Ten healthy young males (22.9 +/- 4.7 years, body mass index: 23.6 +/- 2.5 kg center dot m-2) participated in a strictly controlled repeated-measures bed rest study lasting ten days. High-resolution images were obtained using a hand-held fundus camera at baseline, daily during the 10 days of bed rest, and 1 day after re-ambulation. Retinal vessel analysis was performed using a semi-automated software system to obtain metrics for retinal arteriolar and venular diameters, central retinal artery equivalent and central retinal vein equivalent, respectively. Data analysis employed a mixed linear model. At the end of the bed rest period, a significant decrease in retinal venular diameter was observed, indicated by a significantly lower central retinal vein equivalent (from 226.1 mu m, CI 8.90, to 211.4 mu m, CI 8.28, p = .026), while no significant changes in central retinal artery equivalent were noted. Prolonged bed rest confinement resulted in a significant (up to 6.5%) reduction in retinal venular diameter. These findings suggest that the changes in retinal venular diameter during bedrest may be attributed to plasma volume losses and reflect overall (cardio)-vascular deconditioning.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30201 - Cardiac and Cardiovascular systems
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Scientific Reports
ISSN
2045-2322
e-ISSN
2045-2322
Volume of the periodical
13
Issue of the periodical within the volume
1
Country of publishing house
US - UNITED STATES
Number of pages
7
Pages from-to
19258
UT code for WoS article
001101369900008
EID of the result in the Scopus database
2-s2.0-85175995900