Aberrant microbiomes are associated with increased antibiotic resistance gene load in hybrid mice

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F24%3A00586677" target="_blank" >RIV/67985904:_____/24:00586677 - isvavai.cz</a>

Alternative codes found

RIV/68081766:_____/24:00586677

Result on the web

<a href="https://academic.oup.com/ismecommun/article/4/1/ycae053/7645735?login=true" target="_blank" >https://academic.oup.com/ismecommun/article/4/1/ycae053/7645735?login=true</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1093/ismeco/ycae053" target="_blank" >10.1093/ismeco/ycae053</a>

Result language

angličtina

Original language name

Aberrant microbiomes are associated with increased antibiotic resistance gene load in hybrid mice

Original language description

Antibiotic resistance is a priority public health problem resulting from eco-evolutionary dynamics within microbial communities and their interaction at a mammalian host interface or geographical scale. The links between mammalian host genetics, bacterial gut community, and antimicrobial resistance gene (ARG) content must be better understood in natural populations inhabiting heterogeneous environments. Hybridization, the interbreeding of genetically divergent populations, influences different components of the gut microbial communities. However, its impact on bacterial traits such as antibiotic resistance is unknown. Here, we present that hybridization might shape bacterial communities and ARG occurrence. We used amplicon sequencing to study the gut microbiome and to predict ARG composition in natural populations of house mice (Mus musculus). We compared gastrointestinal bacterial and ARG diversity, composition, and abundance across a gradient of pure and hybrid genotypes in the European House Mouse Hybrid Zone. We observed an increased overall predicted richness of ARG in hybrid mice. We found bacteria-ARG interactions by their co-abundance and detected phenotypes of extreme abundances in hybrid mice at the level of specific bacterial taxa and ARGs, mainly multidrug resistance genes. Our work suggests that mammalian host genetic variation impacts the gut microbiome and chromosomal ARGs. However, it raises further questions on how the mammalian host genetics impact ARGs via microbiome dynamics or environmental covariates.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10602 - Biology (theoretical, mathematical, thermal, cryobiology, biological rhythm), Evolutionary biology

Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2024

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

ISME Communications

ISSN

2730-6151

e-ISSN

2730-6151

Volume of the periodical

4

Issue of the periodical within the volume

1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

5

Pages from-to

ycae053

UT code for WoS article

001234283100001

EID of the result in the Scopus database

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