Cleavage of Early Mouse Embryo with Damaged DNA (vol 23, 3516, 2022)

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F25%3A00618424" target="_blank" >RIV/67985904:_____/25:00618424 - isvavai.cz</a>
Result on the web
<a href="https://www.mdpi.com/1422-0067/26/5/2171" target="_blank" >https://www.mdpi.com/1422-0067/26/5/2171</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/ijms26052171" target="_blank" >10.3390/ijms26052171</a>

Result language
angličtina
Original language name
Cleavage of Early Mouse Embryo with Damaged DNA (vol 23, 3516, 2022)
Original language description
The preimplantation period of embryogenesis is crucial during mammalian ontogenesis. During this period, the mitotic cycles are initiated, the embryonic genome is activated, and the primary differentiation of embryonic cells occurs. All cellular abnormalities occurring in this period are the primary cause of fetal developmental disorders. DNA damage is a serious cause of developmental failure. In the context of DNA damage response on the cellular level, we analyzed the course of embryogenesis and phenotypic changes during the cleavage of a preimplantation embryo. Our results document that DNA damage induced before the resumption of DNA synthesis in a zygote can significantly affect the preimplantation development of the embryo. This developmental ability is related to the level of the DNA damage. We showed that one-cell embryos can correct the first cleavage cycle despite low DNA damage and incomplete replication. It seems that the phenomenon creates a predisposition to a segregation disorder of condensed chromatin that results in the formation of micronuclei in the developmental stages following the first cleavage. We conclude that zygote tolerates a certain degree of DNA damage and considers its priority to complete the first cleavage stage and continue embryogenesis as far as possible.
Czech name
—
Czech description
—

Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10601 - Cell biology

Project
<a href="/en/project/GA20-27742S" target="_blank" >GA20-27742S: Differences in regulation of cell cycle checkpoints between zygote and 2-cell embryo</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)