Expression changes in Fasl-deficient calvaria-derived osteoblasts: an RNA-seq analysis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F25%3A00643833" target="_blank" >RIV/67985904:_____/25:00643833 - isvavai.cz</a>
Alternative codes found
RIV/62157124:16170/25:43882454
Result on the web
<a href="https://www.nature.com/articles/s41597-025-06216-w" target="_blank" >https://www.nature.com/articles/s41597-025-06216-w</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s41597-025-06216-w" target="_blank" >10.1038/s41597-025-06216-w</a>
Alternative languages
Result language
angličtina
Original language name
Expression changes in Fasl-deficient calvaria-derived osteoblasts: an RNA-seq analysis
Original language description
Fasl-deficient (gld) mice display an altered bone phenotype, but the underlying molecular mechanisms remain incompletely understood. Here we evaluated the role of FASL in the gene expression profile of osteogenic cells. To this aim, RNA sequencing was performed on calvaria-derived primary cells from wild-type and Fasl-deficient mice that underwent osteogenic differentiation. The outcome dataset (GSE250608) contains gene expression profiles and enrichment analyses. Based on a log2 fold change >1 and adjusted p-value < 0.01, the lack of Fasl revealed 480 up- and 301 down-regulated genes. These signature changes were annotated to extracellular matrix-related pathways and chemokine signalling. This resource provides a publicly available transcriptomic dataset that can be used to better understand the complex role of FASL in bone biology.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10601 - Cell biology
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Scientific Data
ISSN
2052-4463
e-ISSN
2052-4463
Volume of the periodical
12
Issue of the periodical within the volume
1
Country of publishing house
GB - UNITED KINGDOM
Number of pages
7
Pages from-to
1964
UT code for WoS article
001643651200001
EID of the result in the Scopus database
2-s2.0-105025474701