Extensive Admixture and Selective Pressure Across the Sahel Belt

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985912%3A_____%2F15%3A00453905" target="_blank" >RIV/67985912:_____/15:00453905 - isvavai.cz</a>
Result on the web
<a href="http://gbe.oxfordjournals.org/content/7/12/3484.full.pdf+html" target="_blank" >http://gbe.oxfordjournals.org/content/7/12/3484.full.pdf+html</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1093/gbe/evv236" target="_blank" >10.1093/gbe/evv236</a>

Result language
angličtina
Original language name
Extensive Admixture and Selective Pressure Across the Sahel Belt
Original language description
Genome-wide studies have the potential to reveal powerful insights into the evolution of our species. The populations of the Africa have been exposed to migrations from neighbouring regions but also to intense selective pressures imposed by diet and infectious diseases. We screened 2.5 million single nucleotide polymorphisms in 161 individuals from 13 Sahelian populations and included both nomadic and sedentary groups. We confirmed the role of the Sahel Belt as a corridor for human migrations across the African continent. Strong admixture was observed in both Central and Eastern Sahelian populations, with North Africans and Near Eastern/Arabians, respectively, but it was inexistent in Western Sahelian populations. The DARC gene region in Arabs and Nubians was enriched for African ancestry, whereas the RAB3GAP1/LCT/MCM6 region in Oromo, the TAS2R gene family in Fulani, and the ALMS1/NAT8 in Turkana and Samburu were enriched for non-African ancestry. Some genomic regions were selected across the Belt, the most striking example being the malaria-related DARC gene. Others were Western-specific (oxytocin, calcium, and heart pathways), Eastern-specific (lipid pathways), or even population-restricted (TAS2R genes in Fulani, which may reflect sexual selection).
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
AC - Archaeology, anthropology, ethnology
OECD FORD branch
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Project
<a href="/en/project/GA13-37998S" target="_blank" >GA13-37998S: Genetic imprints of food-production systems in human populations</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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