Inhibition of gap-junctional intercellular communication and activation of mitogen-activated protein kinases by cyanobacterial extracts-Indications of novel tumor-promoting cyanotoxins?
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985939%3A_____%2F10%3A00349719" target="_blank" >RIV/67985939:_____/10:00349719 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14310/10:00049612
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Inhibition of gap-junctional intercellular communication and activation of mitogen-activated protein kinases by cyanobacterial extracts-Indications of novel tumor-promoting cyanotoxins?
Original language description
Gap-junctional intercellular communication (GJIC) and mitogen-activated protein kinases (MAPKs), well-established biomarkers of tumor promotion, were affected by cyanobacterial extracts in in vitro experiments with rat liver epithelial cells. Since the observed effects of cyanobacterial extracts did not correlate with the content of known hepatotoxic cyanotoxins, and the pure toxins (microcystin, cylindrospermopsin, lipopolysaccharides) affected neither GJIC nor MAPKs, the effects were most likely induced by not-yet characterized chemicals of produced by cyanobacteria. These mechanisms (inhibition of GJIC, activation of MAPKs) and chemicals may thus contribute to the tumor promoting activity of toxic cyanobacteria.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EF - Botany
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GA524%2F08%2F0496" target="_blank" >GA524/08/0496: Tumor promotional mechanisms of cyanobacterial metabolites</a><br>
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2010
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Toxicon
ISSN
0041-0101
e-ISSN
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Volume of the periodical
55
Issue of the periodical within the volume
1
Country of publishing house
GB - UNITED KINGDOM
Number of pages
9
Pages from-to
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UT code for WoS article
000273921500016
EID of the result in the Scopus database
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