Biopolymer of Dictyosphaerium chlorelloides chemical characterization and biological effects

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985939%3A_____%2F18%3A00490105" target="_blank" >RIV/67985939:_____/18:00490105 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.ijbiomac.2018.03.052" target="_blank" >http://dx.doi.org/10.1016/j.ijbiomac.2018.03.052</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.ijbiomac.2018.03.052" target="_blank" >10.1016/j.ijbiomac.2018.03.052</a>

Result language
angličtina
Original language name
Biopolymer of Dictyosphaerium chlorelloides chemical characterization and biological effects
Original language description
Some microalgae are producers of high-value phytochemicals of interest for industrial applications. Cultivation of Dictyosphaerium chlorelloides microalgae yielded about 1 g/L of a viscous exobiopolymer with a high molecular weight (M-p, = 9.6 x 10(5) g/mol). Its proteoglycan character was confirmed by the presence of proteins and carbohydrates. Dominant sugars of the biopolymer were galactose and its methyl-derivatives (similar to 42 wt%), rhamnose (18 wt%), mannose (14 wt%) and unidentified methyl-hexoses (12 wt%). Besides, glucose and 3-0-methyl derivative (8 wt%), xylose and 4-0-methyl-derivative (4 wt%), and arabinose (2 wt%) were found. Methylation analysis indicated a complex chemical structure. Immunobiological studies revealed the effective anti-proliferative capacity of the biopolymer in vitro in both cancer and non-cancer cell lines. Based on in vitro exposition using a reconstructed 3-D tissue model, a good bioavailability and a low toxicity of the biopolymer have been found. Exposition of RAW 264.7 macrophages to the biopolymer resulted into significant immunostimulation of pro and anti-inflammatory cytokines, and decreased free radical cell release.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10404 - Polymer science

Project
<a href="/en/project/TE01020080" target="_blank" >TE01020080: Biorefinery Research Centre of Competence</a><br>
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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