Anxiety in Duckweed–Metabolism and Effect of Diazepam on Lemna minor
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985939%3A_____%2F22%3A00563405" target="_blank" >RIV/67985939:_____/22:00563405 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14160/22:00126390
Result on the web
<a href="https://doi.org/10.3390/w14091484" target="_blank" >https://doi.org/10.3390/w14091484</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/w14091484" target="_blank" >10.3390/w14091484</a>
Alternative languages
Result language
angličtina
Original language name
Anxiety in Duckweed–Metabolism and Effect of Diazepam on Lemna minor
Original language description
The fate of pharmaceuticals in the human body, from their absorption to excretion is well studied. However, medication often leaves the patient's body in an unchanged or metabolised, yet still active, form. Diazepam and its metabolites, ranging up to 100 mu g/L, have been detected in surface waters worldwide, therefore, the question of its influence on model aquatic plants, such as duckweed (Lemna minor), needs to be addressed. Lemna was cultivated in a Steinberg medium containing diazepam in three concentrations-0.2, 20, and 2000 mu g/L. The activity of superoxide dismutase (SOD) and catalase (CAT), leaf count, mass, and the fluorescence quantum yield of photosynthesis were assessed. The medium was also analysed by LC-MS/MS to determine the concentration of diazepam metabolites. Our results show no negative impact of diazepam on Lemna minor, even in concentrations significantly higher than those that are ecotoxicologically relevant. On the contrary, the influence of diazepam on Lemna suggests growth stimulation and a similarity to the effect diazepam has on the human body. The comparison to the human body may be accurate because gamma-Aminobutyric acid-like (GABA-like) receptors responsible for the effect in humans have also been recently described in plants. Therefore, our results can open an interesting scientific area, indicating that GABA receptors and interference with benzodiazepines are evolutionarily much older than previously anticipated. This could help to answer more questions related to the reaction of aquatic organisms to micropollutants such as psychopharmaceuticals.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10618 - Ecology
Result continuities
Project
<a href="/en/project/SS01020006" target="_blank" >SS01020006: Hybrid plasma-chemical oxidation for advanced decontamination of micro-pollutants and waste water disinfection</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Water
ISSN
2073-4441
e-ISSN
2073-4441
Volume of the periodical
14
Issue of the periodical within the volume
9
Country of publishing house
CH - SWITZERLAND
Number of pages
12
Pages from-to
1484
UT code for WoS article
000796106900001
EID of the result in the Scopus database
2-s2.0-85130189332