Impact of whole-genome duplications on structural variant evolution in Cochlearia
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985939%3A_____%2F24%3A00587671" target="_blank" >RIV/67985939:_____/24:00587671 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11310/24:10485911
Result on the web
<a href="https://doi.org/10.1038/s41467-024-49679-y" target="_blank" >https://doi.org/10.1038/s41467-024-49679-y</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s41467-024-49679-y" target="_blank" >10.1038/s41467-024-49679-y</a>
Alternative languages
Result language
angličtina
Original language name
Impact of whole-genome duplications on structural variant evolution in Cochlearia
Original language description
Polyploidy, the result of whole-genome duplication (WGD), is a major driver of eukaryote evolution. Yet WGDs are hugely disruptive mutations, and we still lack a clear understanding of their fitness consequences. Here, we study whether WGDs result in greater diversity of genomic structural variants (SVs) and how they influence evolutionary dynamics in a plant genus, Cochlearia (Brassicaceae). By using long-read sequencing and a graph-based pangenome, we find both negative and positive interactions between WGDs and SVs. Masking of recessive mutations due to WGDs leads to a progressive accumulation of deleterious SVs across four ploidal levels (from diploids to octoploids), likely reducing the adaptive potential of polyploid populations. However, we also discover putative benefits arising from SV accumulation, as more ploidy-specific SVs harbor signals of local adaptation in polyploids than in diploids. Together, our results suggest that SVs play diverse and contrasting roles in the evolutionary trajectories of young polyploids.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10611 - Plant sciences, botany
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Nature Communications
ISSN
2041-1723
e-ISSN
2041-1723
Volume of the periodical
15
Issue of the periodical within the volume
1
Country of publishing house
US - UNITED STATES
Number of pages
13
Pages from-to
5377
UT code for WoS article
001255072700029
EID of the result in the Scopus database
2-s2.0-85196826371