Inhibition of gap-junctional intercellular communication by environmentally occurring polycyclic aromatic hydrocarbons.
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F02%3A17023001" target="_blank" >RIV/68081707:_____/02:17023001 - isvavai.cz</a>
Alternative codes found
RIV/00027162:_____/02:90000008
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Inhibition of gap-junctional intercellular communication by environmentally occurring polycyclic aromatic hydrocarbons.
Original language description
The removal cells from growth suppression via the inhibition of gap-junctional intercellular communication (GJIC) is supposed to contribute to tumor promotion. Inhibition of GJIC measured with an in vitro WB-F344 rat liver epithelial cell system was usedto assess the relative potencies of polycyclic aromatic hydrocarbons (PAHs) to inhibit GJIC. Although micromolar concentrations of PAHs were required to reach the inhibition level equal to the model tumor promoter phorbol 12-myristate 13-acetate twelveof the PAHs under study were found to be strong inhibitors of GJIC (strongest effects were observed at fluoranthene, picene, 5-methylchrysene and nine additional PAHs). Arbitrary values of inhibition equivalency factors (GJIC-IEFs) ranging from 0 (non-inhibiting PAHs) to 10.0 (strongest inhibitors), were suggested, suitable for the purposes of environmental risk assessment.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
BO - Biophysics
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2002
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Toxicological Sciences
ISSN
1096-6080
e-ISSN
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Volume of the periodical
65
Issue of the periodical within the volume
1
Country of publishing house
US - UNITED STATES
Number of pages
9
Pages from-to
43-51
UT code for WoS article
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EID of the result in the Scopus database
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