Inhibition of GAP junctional intercellular comunication by noncoplanar polychlorinated biphenyls: inhibitory potencies and screening for potential mode(s) of action

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F03%3A00008481" target="_blank" >RIV/00027162:_____/03:00008481 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Inhibition of GAP junctional intercellular comunication by noncoplanar polychlorinated biphenyls: inhibitory potencies and screening for potential mode(s) of action

Original language description

Inhibition of gap junctional intercellular communication (GJIC) belongs among critical epigenetic events of tumor promotion. We determined relative potencies of a series of environmentally relevant PCB congeners to inhibit GJIC in vitro in a rat liver epithelial WB-F344 cells. The nonplanar PCBs were potent inhibitors of GJIC, whereas the dioxin-like PCBs did not inhibit GJIC. In contrast to phorbol ester and epidermal growth factor, prototypal tumor promoters, noncoplanar PCB 153 elicited a long-term downregulation of GJIC (up to 48 h). Various intracellular signaling pathways potentially involved in inhibition of GJIC were screened by using specific chemical probes inhibiting serine/threonine kinases, tyrosine kinases and phspholipases. Phosphocholine/specific phospholipase or sphingomyelinase and a tyrosine kinase might be upstream regulators of PCB/induced inhibition of GJIC.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CE - Biochemistry

OECD FORD branch

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Project

<a href="/en/project/GA525%2F00%2FD101" target="_blank" >GA525/00/D101: In vitro methods for detection and studies of epigenetic toxicity of xenobiotics</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2003

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Toxicological Sciences

ISSN

1096-6080

e-ISSN

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Volume of the periodical

76

Issue of the periodical within the volume

1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

10

Pages from-to

102-111

UT code for WoS article

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EID of the result in the Scopus database

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