Recognition of DNA modified by antitumor cisplatin by 'latent' and 'active' protein p53.

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F03%3A17033016" target="_blank" >RIV/68081707:_____/03:17033016 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Recognition of DNA modified by antitumor cisplatin by 'latent' and 'active' protein p53.

Original language description

Binding of active, latent and in vitro-activated p53 protein to DNA fragments globally modified by antitumor cisplatin was studied using electrophoretic mobility shift assay in agarose gels and immunoblotting analysis. Both latent and active p53 forms bound to platinated random sequences of DNA with a higher affinity than to unmodified DNA. The latent form exhibited a more pronounced selectivity for platinated DNA than the active p53.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

BO - Biophysics

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2003

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Biochemical Pharmacology

ISSN

0006-2952

e-ISSN

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Volume of the periodical

65

Issue of the periodical within the volume

8

Country of publishing house

US - UNITED STATES

Number of pages

12

Pages from-to

1305-1316

UT code for WoS article

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EID of the result in the Scopus database

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