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Melting of cross-linked DNA V. Cross-linking effect caused by local stabilization of the double helix.

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F03%3A17033293" target="_blank" >RIV/68081707:_____/03:17033293 - isvavai.cz</a>

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Melting of cross-linked DNA V. Cross-linking effect caused by local stabilization of the double helix.

  • Original language description

    The stabilization of DNA can be affected by all the types of chemical modifications of DNA (interstrand cross-links, intrastrand cross-links or monofunctional adducts) which give rise to a strong enough local stabilization of the double helix. Our calculation demonstrates that an increase in stability by 25 to 30 kcal in the free energy of a single base pair of the double helix is sufficient for conserving the helicity of this base pair and preventing strand separation after melting of ordinary base pairs. For the situation where there is more then one stabilized site in a DNA duplex, a lower stabilization per site is sufficient (18 - 20 kcal). A substantial increase in DNA stability was found in various experimental studies for some metal-based antitumor compounds. Stretches of GC pairs more than 25 bp in length inserted into poly(AT) DNA also exhibit properties of stabilizing interstrand cross-links.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    BO - Biophysics

  • OECD FORD branch

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Others

  • Publication year

    2003

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Journal of Biomolecular Structure and Dynamics

  • ISSN

    0739-1102

  • e-ISSN

  • Volume of the periodical

    20

  • Issue of the periodical within the volume

    4

  • Country of publishing house

    CZ - CZECH REPUBLIC

  • Number of pages

    13

  • Pages from-to

    533-545

  • UT code for WoS article

  • EID of the result in the Scopus database