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DNA interacions of new antitumor platinum complexes with trans geometry activated by a 2-metylbutylamine or sec-butylamine ligand

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F04%3A00104629" target="_blank" >RIV/68081707:_____/04:00104629 - isvavai.cz</a>

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    DNA interacions of new antitumor platinum complexes with trans geometry activated by a 2-metylbutylamine or sec-butylamine ligand

  • Original language description

    The global modification of mammalian and plasmid DNAs by novel platinum compounds, trans-[PtCl2(NH3)(Am)], where Am = 2-methylbutylamine or sec-butylamine was investigated in cell-free media using various biochemical and biophysical methods. These modifications were analyzed in the context of the activity of these new compounds in several tumor cell lines including those resistant to antitumor cis-diamminedichloroplatinum(II) (cisplatin).

  • Czech name

    Interakce DNA s novými protinádorově účinnými komplexy platiny s geometrií trans kativovanou 2-metylbutylaminem nebo sec-butylamine ligandem

  • Czech description

    Byla studována modifikace savčí a plasmidové DNA novými komplexy platiny trans-[PtCl2(NH3)(Am)], kde Am = 2-methylbutylamin nebo sec-butylamine různými biochemickými a biofyzikálními metodami. Tyoto modifikace byly analyzovány v kontextu aktivity těchtonových sloučenin v několika nádorových buněčných liniích včetně linií tresistentních vůči působení protinádorově účinného cis-diamminedichloroplatnatého komplexu (cisplatiny).

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    BO - Biophysics

  • OECD FORD branch

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Others

  • Publication year

    2004

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Biochemical Pharmacology

  • ISSN

    0006-2952

  • e-ISSN

  • Volume of the periodical

    67

  • Issue of the periodical within the volume

    6

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    13

  • Pages from-to

    1097-1109

  • UT code for WoS article

  • EID of the result in the Scopus database