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EN
ČeštinaEnglish

DNA interacions of new antitumor platinum complexes with trans geometry activated by a 2-metylbutylamine of sec-butylamine ligand.

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F04%3A17033296" target="_blank" >RIV/68081707:_____/04:17033296 - isvavai.cz</a>

  • Result on the web

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  • DOI - Digital Object Identifier

    —

Alternative languages

  • Result language

    angličtina

  • Original language name

    DNA interacions of new antitumor platinum complexes with trans geometry activated by a 2-metylbutylamine of sec-butylamine ligand.

  • Original language description

    The global modification of DNA by novel platinum compounds, trans-[PtCl2(NH3)(Am)], where Am = 2-methylbutylamine or sec-butylamine was investigated in cell-free media. The results showed that the replacement of one ammine group by 2-methylbutylamine orsec-butylamine ligand in clinically ineffective trans-diamminedichloroplatinum(II) (transplatin) resulted in a radical enhancement of its activity in tumor cell lines so that they are more cytotoxic than cisplatin and exhibited significant antitumor activity including activity in cisplatin-resistant tumor cells. Importantly, this replacement also markedly altered DNA binding mode of transplatin and reduced the efficiency of repair systems to remove the adducts of the new analogues from DNA.

  • Czech name

    —

  • Czech description

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Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    BO - Biophysics

  • OECD FORD branch

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Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Others

  • Publication year

    2004

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Biochemical Pharmacology

  • ISSN

    0006-2952

  • e-ISSN

    —

  • Volume of the periodical

    67

  • Issue of the periodical within the volume

    6

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    13

  • Pages from-to

    1097-1109

  • UT code for WoS article

    —

  • EID of the result in the Scopus database

    —

Similar results(10)

DNA interactions of new antitumor platinum complexes with trans geometry activated by a 2-metylbutylamine or sec-butylamine ligand.DNA interacions of new antitumor platinum complexes with trans geometry activated by a 2-metylbutylamine or sec-butylamine ligandDNA binding mode of the cis and trans geometries of new antitumor nonclassical platinum complexes containing piperidine, piperazine or 4-picoline ligand in cell-free media. Relations to their activity in cancer cell lines.