All

What are you looking for?

All
Projects
Results
Organizations

Quick search

  • Projects supported by TA ČR
  • Excellent projects
  • Projects with the highest public support
  • Current projects

Smart search

  • That is how I find a specific +word
  • That is how I leave the -word out of the results
  • “That is how I can find the whole phrase”

Differential recognition by the tumor suppressor protein p53 of DNA modified by the novel antitumor trinuclear platinum drug BBR3464 and cisplatin

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F04%3A00104638" target="_blank" >RIV/68081707:_____/04:00104638 - isvavai.cz</a>

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Differential recognition by the tumor suppressor protein p53 of DNA modified by the novel antitumor trinuclear platinum drug BBR3464 and cisplatin

  • Original language description

    The results indicate that structurally different DNA adducts of antitumor trinuclear platinum compound BBR3464 and cisplatin exhibit a different efficiency to affect the binding affinity of the modified DNA to p53 protein. It has been suggested that different structural perturbations induced in DNA by the adducts of BBR3464 and cisplatin produce differential response to p53 protein activation.

  • Czech name

    Odlišné rozlišení DNA modifikované novým protinádorově účinným trojjaderným komplexem platiny BBR3464 a cisplatinou nádorově supresorovým proteinem p53

  • Czech description

    Výsledky ukazují, že strukturně odlišné adukty protinádorově účinného trojjaderného komplexu platiny BBR3464 a cisplatiny vykazují odlišnou účinnost ovlivňovat vazebnou afinitu modifikované DNA k proteinu p53. Bylo navrženo, že odlišná narušení strukturyvyvolaná v DNA adukty BBR3464 a cisplatiny jsou signálem pro odlišnou odpověď na aktivaci proteinu p53.

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    BO - Biophysics

  • OECD FORD branch

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Others

  • Publication year

    2004

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Nucleic Acids Research

  • ISSN

    0305-1048

  • e-ISSN

  • Volume of the periodical

    32

  • Issue of the periodical within the volume

    18

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    7

  • Pages from-to

    5546-5552

  • UT code for WoS article

  • EID of the result in the Scopus database