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Activation of ERK1/2 and p38 kinases by polycyclic aromatic hydrocarbons in rat liver epithelial cells is associated with induction of apoptosis

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F06%3A00048081" target="_blank" >RIV/68081707:_____/06:00048081 - isvavai.cz</a>

  • Alternative codes found

    RIV/00027162:_____/06:#0000074

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Activation of ERK1/2 and p38 kinases by polycyclic aromatic hydrocarbons in rat liver epithelial cells is associated with induction of apoptosis

  • Original language description

    The present data suggest that both ERK1/2 and p38 are activated in response to dibenzo[a,l]pyrenu (DBalP) and that they might be involved in regulation of cellular response to DNA damage induced by DBalP. On the other hand, neither kinase is involved inthe release from contact inhibition induced by PAHs.

  • Czech name

    Aktivace kináz ERK1/2 a p38 polycyklickými aromatickými uhlovodíky v jaterních epiteliálních buňkách potkana souvisí s indukcí apoptózy

  • Czech description

    Prezentovaná data ukazují, že ERK1/2 i p38 jsou aktivovány v odpovědi na působení dibenzo[al]pyrenu (DBalP) a že se mohou podílet na regulaci buněčné odpovědi na poškození DNA způsobené DBalP. Na druhou stranu, ani jedna z těchto kináz se nepodílí na uvolnění z kontaktní inhibice prostřednictvím PAU.

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    BO - Biophysics

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/GP525%2F01%2FD076" target="_blank" >GP525/01/D076: Activation of MAP protein kinase pathways by polycyclic aromatic hydrocarbons in vitro - a potential nongenotoxic mechanism underlying the effects of environmen</a><br>

  • Continuities

    Z - Vyzkumny zamer (s odkazem do CEZ)

Others

  • Publication year

    2006

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Toxicology and Applied Pharmacology

  • ISSN

    0041-008X

  • e-ISSN

  • Volume of the periodical

    211

  • Issue of the periodical within the volume

    3

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    11

  • Pages from-to

    198-208

  • UT code for WoS article

  • EID of the result in the Scopus database