Substitution of adenine for guanine in the quadruplex-forming human telomere DNA sequence G3(T2AG3)3

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F09%3A00329204" target="_blank" >RIV/68081707:_____/09:00329204 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Substitution of adenine for guanine in the quadruplex-forming human telomere DNA sequence G3(T2AG3)3

Original language description

We have studied the formation and structural properties of quadruplexes of the human telomeric DNA sequence G3(T2AG3)3 and related sequences in which each guanine base was replaced by an adenine base. None of these single base substitutions hindered theformation of antiparallel quadruplexes in NaCl and KCl solutions. Effect of substitution did differ, however, depending on the position of the substituted base. The A-for-G substitution in the middle quartet of the antiparallel basket scaffold led to themost distorted and least stable structures and these sequences preferred to form biomolecular quadruplexes.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

BO - Biophysics

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2009

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Biochimie

ISSN

0300-9084

e-ISSN

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Volume of the periodical

91

Issue of the periodical within the volume

2

Country of publishing house

FR - FRANCE

Number of pages

9

Pages from-to

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UT code for WoS article

000263813300002

EID of the result in the Scopus database

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