Modulation of metabolic activity of phagocytes by antihistamines.
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F11%3A00441596" target="_blank" >RIV/68081707:_____/11:00441596 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.2478/v10102-011-0004-z" target="_blank" >http://dx.doi.org/10.2478/v10102-011-0004-z</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2478/v10102-011-0004-z" target="_blank" >10.2478/v10102-011-0004-z</a>
Alternative languages
Result language
angličtina
Original language name
Modulation of metabolic activity of phagocytes by antihistamines.
Original language description
The purpose of the study was to investigate the effects of H(1)-antihistamines of the 1(st) generation (antazoline, bromadryl, brompheniramine, dithiaden, cyclizine, chlorcyclizine, chlorpheniramine, clemastine) and the 2(nd) generation (acrivastine, ketotifen, and loratadine) on the respiratory burst of phagocytes. Reactive oxygen species generation in neutrophils isolated from rat blood was measured using luminol-enhanced chemiluminescence. Changes in nitrite formation and iNOS protein expression by RAW 264.7 macrophages were analysed using Griess reaction and Western blotting. The antioxidative properties of drugs in cell-free systems were detected spectrophotometrically, luminometrically, fluorimetrically, and amperometrically. The majority of theH(1)-antihistamines tested (bromadryl, brompheniramine, chlorcyclizine, chlorpheniramine, clemastine, dithiaden, and ketotifen) exhibited a significant inhibitory effect on the chemiluminescence activity of phagocytes.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
BO - Biophysics
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Interdisciplinary Toxicology
ISSN
1337-6853
e-ISSN
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Volume of the periodical
4
Issue of the periodical within the volume
1
Country of publishing house
SK - SLOVAKIA
Number of pages
7
Pages from-to
9-15
UT code for WoS article
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EID of the result in the Scopus database
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