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Modulation of metabolic activity of phagocytes by antihistamines.

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F11%3A00441596" target="_blank" >RIV/68081707:_____/11:00441596 - isvavai.cz</a>

  • Result on the web

    <a href="http://dx.doi.org/10.2478/v10102-011-0004-z" target="_blank" >http://dx.doi.org/10.2478/v10102-011-0004-z</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.2478/v10102-011-0004-z" target="_blank" >10.2478/v10102-011-0004-z</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Modulation of metabolic activity of phagocytes by antihistamines.

  • Original language description

    The purpose of the study was to investigate the effects of H(1)-antihistamines of the 1(st) generation (antazoline, bromadryl, brompheniramine, dithiaden, cyclizine, chlorcyclizine, chlorpheniramine, clemastine) and the 2(nd) generation (acrivastine, ketotifen, and loratadine) on the respiratory burst of phagocytes. Reactive oxygen species generation in neutrophils isolated from rat blood was measured using luminol-enhanced chemiluminescence. Changes in nitrite formation and iNOS protein expression by RAW 264.7 macrophages were analysed using Griess reaction and Western blotting. The antioxidative properties of drugs in cell-free systems were detected spectrophotometrically, luminometrically, fluorimetrically, and amperometrically. The majority of theH(1)-antihistamines tested (bromadryl, brompheniramine, chlorcyclizine, chlorpheniramine, clemastine, dithiaden, and ketotifen) exhibited a significant inhibitory effect on the chemiluminescence activity of phagocytes.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    BO - Biophysics

  • OECD FORD branch

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2011

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Interdisciplinary Toxicology

  • ISSN

    1337-6853

  • e-ISSN

  • Volume of the periodical

    4

  • Issue of the periodical within the volume

    1

  • Country of publishing house

    SK - SLOVAKIA

  • Number of pages

    7

  • Pages from-to

    9-15

  • UT code for WoS article

  • EID of the result in the Scopus database