On the interaction between [Ru(NH3)(6)](3+) and the G-quadruplex forming thrombin binding aptamer sequence

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F13%3A00399496" target="_blank" >RIV/68081707:_____/13:00399496 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.jinorgbio.2013.05.014" target="_blank" >http://dx.doi.org/10.1016/j.jinorgbio.2013.05.014</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jinorgbio.2013.05.014" target="_blank" >10.1016/j.jinorgbio.2013.05.014</a>

Result language
angličtina
Original language name
On the interaction between [Ru(NH3)(6)](3+) and the G-quadruplex forming thrombin binding aptamer sequence
Original language description
The interaction between the thrombin binding aptamer (TBA), a G-quadruplex forming DNA sequence, and the electroactive hexaammineruthenium(III) cation has been studied by electrochemical methods and circular dichroism spectroscopy. When TBA is immobilised on a gold surface in a typical aptasensor configuration, the [Ru(NH3)(6)](3+) cation can be bound to the electrode surface through its interaction with the TBA sequence. This interaction is strong enough to enable-the-ruthenium complex-to remain at thesurface when the electrode is immersed in an electrolyte free of [Ru(NH3)(6)](3+), meaning that the complex does not diffuse back into the solution.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
BO - Biophysics
OECD FORD branch
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Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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