Nuclear Structures Surrounding Internal Lamin Invaginations
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F14%3A00427969" target="_blank" >RIV/68081707:_____/14:00427969 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1002/jcb.24681" target="_blank" >http://dx.doi.org/10.1002/jcb.24681</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/jcb.24681" target="_blank" >10.1002/jcb.24681</a>
Alternative languages
Result language
angličtina
Original language name
Nuclear Structures Surrounding Internal Lamin Invaginations
Original language description
A- and C-type lamins are intermediate filament proteins responsible for the maintenance of nuclear shape and most likely nuclear architecture. Here, we propose that pronounced invaginations of A/C-type lamins into the nuclear interior represent channelsfor the transport of regulatory molecules to and from nuclear and nucleolar regions. Using fluorescent protein technology and immunofluorescence, we show that A-type lamin channels interact with several nuclear components, including fibrillarin- and UBF-positive regions of nucleoli, foci of heterochromatin protein 1 , polycomb group bodies, and genomic regions associated with DNA repair. Similar associations were observed between A/C-type lamin channels and nuclear pores, lamin-associated protein LAP2,and promyelocytic leukemia nuclear bodies. Interestingly, regions with high levels of A/C-type lamins had low levels of B-type lamins, and vice versa.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
BO - Biophysics
OECD FORD branch
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Result continuities
Project
<a href="/en/project/LD11020" target="_blank" >LD11020: Epigenetics normal and tumor cells.</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Cellular Biochemistry
ISSN
0730-2312
e-ISSN
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Volume of the periodical
115
Issue of the periodical within the volume
3
Country of publishing house
US - UNITED STATES
Number of pages
12
Pages from-to
476-487
UT code for WoS article
000330906300007
EID of the result in the Scopus database
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