The histamine H-4 receptor is a potent inhibitor of adhesion-dependent degranulation in human neutrophils
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F14%3A00431753" target="_blank" >RIV/68081707:_____/14:00431753 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1189/jlb.2AB0813-432RR" target="_blank" >http://dx.doi.org/10.1189/jlb.2AB0813-432RR</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1189/jlb.2AB0813-432RR" target="_blank" >10.1189/jlb.2AB0813-432RR</a>
Alternative languages
Result language
angličtina
Original language name
The histamine H-4 receptor is a potent inhibitor of adhesion-dependent degranulation in human neutrophils
Original language description
The histamine H-4 receptor regulates the inflammatory response. However, it is not known whether this receptor has a functional role in human neutrophils. We found that fMLP (1 mu M), but not histamine (0.1-1 mu M), induced Mac-1-dependent adhesion, polarization, and degranulation (release of lactoferrin). A pretreatment of neutrophils with histamine (0.001-1 mu M) or JNJ 28610244 (0.1-10 mu M), a specific H-4 receptor agonist, led to inhibition of degranulation. Total inhibition of degranulation was obtained with 0.1 mu M histamine and 10 mu M JNJ 28610244. Furthermore, such inhibition by histamine of degranulation was reversed by JNJ 7777120 and JNJ 28307474, two selective H-4 receptor antagonists. However, neither histamine nor the H-4 receptor agonist JNJ 28610244 prevented fMLP-induced, Mac-1-dependent adhesion, indicating that the H-4 receptor may block signals emanating from Mac-1-controlling degranulation. Likewise, engagement of the H-4 receptor by the selective agonist JNJ 28
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
BO - Biophysics
OECD FORD branch
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Result continuities
Project
<a href="/en/project/EE2.3.30.0030" target="_blank" >EE2.3.30.0030: Development of human resources in the field of cell biology</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Leukocyte Biology
ISSN
0741-5400
e-ISSN
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Volume of the periodical
96
Issue of the periodical within the volume
3
Country of publishing house
US - UNITED STATES
Number of pages
8
Pages from-to
411-418
UT code for WoS article
000340829400007
EID of the result in the Scopus database
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