Fibroblast Growth Factor Receptor 3 Interacts with and Activates TGF beta-Activated Kinase 1 Tyrosine Phosphorylation and NFkB Signaling in Multiple Myeloma and Bladder Cancer

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F14%3A00440592" target="_blank" >RIV/68081707:_____/14:00440592 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1371/journal.pone.0086470" target="_blank" >http://dx.doi.org/10.1371/journal.pone.0086470</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1371/journal.pone.0086470" target="_blank" >10.1371/journal.pone.0086470</a>

Result language

angličtina

Original language name

Fibroblast Growth Factor Receptor 3 Interacts with and Activates TGF beta-Activated Kinase 1 Tyrosine Phosphorylation and NFkB Signaling in Multiple Myeloma and Bladder Cancer

Original language description

Cancer is a major public health problem worldwide. In the United States alone, 1 in 4 deaths is due to cancer and for 2013 a total of 1,660,290 new cancer cases and 580,350 cancer-related deaths are projected. Comprehensive profiling of multiple cancer genomes has revealed a highly complex genetic landscape in which a large number of altered genes, varying from tumor to tumor, impact core biological pathways and processes. This has implications for therapeutic targeting of signaling networks in the development of treatments for specific cancers. The NF kappa B transcription factor is constitutively active in a number of hematologic and solid tumors, and many signaling pathways implicated in cancer are likely connected to NF kappa B activation. A critical mediator of NF kappa B activity is TGF beta-activated kinase 1 (TAK1). Here, we identify TAK1 as a novel interacting protein and target of fibroblast growth factor receptor 3 (FGFR3) tyrosine kinase activity.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

BO - Biophysics

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

PLoS ONE

ISSN

1932-6203

e-ISSN

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Volume of the periodical

9

Issue of the periodical within the volume

1

Country of publishing house

US - UNITED STATES

Number of pages

11

Pages from-to

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UT code for WoS article

000330288000101

EID of the result in the Scopus database

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