Increasing DNA reactivity and in vitro antitumor activity of trans diiodido Pt(II) complexes with UVA light

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F15%3A00456686" target="_blank" >RIV/68081707:_____/15:00456686 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.jinorgbio.2015.07.008" target="_blank" >http://dx.doi.org/10.1016/j.jinorgbio.2015.07.008</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jinorgbio.2015.07.008" target="_blank" >10.1016/j.jinorgbio.2015.07.008</a>

Result language
angličtina
Original language name
Increasing DNA reactivity and in vitro antitumor activity of trans diiodido Pt(II) complexes with UVA light
Original language description
Trans diiodido platinum(II) complexes beating the same as well as different aliphatic amines (mixed-amines) have interesting biological activity; cytotoxicity and interactions with some important biological models have already been demonstrated. Herein we described the interaction of such compounds with ct-DNA, supercoiled and linearized plasmid DNA and 5-GMP. Interestingly, UV irradiation of these compounds results in an increase in reactivity towards DNA and 5-GMP in such model systems. Additionally,the cytotoxicity of the trans-Pt(II) complexes towards human cancer cells is noticeably increased when treatment is combined for 90 min with UVA-irradiation. With this work we provide evidence that trans diiodido compounds can be activated by UV-light over relatively short treatment times. (C) 2015 Elsevier Inc. All rights reserved.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
BO - Biophysics
OECD FORD branch
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Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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