Diazido mixed-amine platinum(IV) anticancer complexes activatable by visible-light form novel DNA adducts

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F13%3A33147621" target="_blank" >RIV/61989592:15310/13:33147621 - isvavai.cz</a>

Alternative codes found

RIV/68081707:_____/13:00394801

Result on the web

<a href="http://onlinelibrary.wiley.com/doi/10.1002/chem.201300374/pdf" target="_blank" >http://onlinelibrary.wiley.com/doi/10.1002/chem.201300374/pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/chem.201300374" target="_blank" >10.1002/chem.201300374</a>

Result language

angličtina

Original language name

Diazido mixed-amine platinum(IV) anticancer complexes activatable by visible-light form novel DNA adducts

Original language description

Photoactivatable PtIV prodrugs offer the potential of targeted drug release and new mechanisms of action. The synthesis, X-ray crystallographic, spectroscopic properties, cytotoxicity and DNA interactions of photoactivatable diazido complexes trans,trans,trans-[Pt(N3)2(OH)2(MA)(Py)] (1; MA=methylamine, Py=pyridine) and trans,trans,trans-[Pt(N3)2(OH)2(MA)(Tz)] (2; Tz=thiazole) have been reported. It was shown that complexes 1 and 2 can give rapid potent photocytotoxicity and novel DNA lesions in cancer cells, with no activity in the absence of irradiation.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

BO - Biophysics

OECD FORD branch

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Project

<a href="/en/project/GAP301%2F10%2F0598" target="_blank" >GAP301/10/0598: Metallodrugs based on osmium, platinum and ruthenium complexes. From mechanistic studies to novel, more efficient chemotherapy of cancer</a><br>

Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Chemistry: A European Journal

ISSN

0947-6539

e-ISSN

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Volume of the periodical

19

Issue of the periodical within the volume

29

Country of publishing house

DE - GERMANY

Number of pages

14

Pages from-to

9578-9591

UT code for WoS article

000321431600029

EID of the result in the Scopus database

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