A potent cytotoxic photoactivated platinum complex
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F07%3A00345270" target="_blank" >RIV/68081707:_____/07:00345270 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
A potent cytotoxic photoactivated platinum complex
Original language description
Platinum(IV)diazido complexes containing cis-diam(m)ine ligands are relatively inert in the dark. We report here the dramatic effects arising from incorporation of a pyridine ligand in place of an ammine ligand. trans,trans,trans-[Pt(N3)2(OH)2(NH3)(py)]is highly phototoxic and reacts with guanine derivatives and with DNA to give unusual PtII adducts not readily formed in the absence of light.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
BO - Biophysics
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2007
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Proceedings of the National Academy of Sciences of the United States of America
ISSN
0027-8424
e-ISSN
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Volume of the periodical
104
Issue of the periodical within the volume
52
Country of publishing house
US - UNITED STATES
Number of pages
6
Pages from-to
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UT code for WoS article
000252077400024
EID of the result in the Scopus database
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