Combined theoretical and computational study of interstrand DNA guanine-guanine cross-linking by trans-[Pt(pyridine)2] derived from the photoactivated prodrug trans,trans,trans-[Pt(N3)2(OH)2(pyridine)2]
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F12%3A00378736" target="_blank" >RIV/68081707:_____/12:00378736 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1021/ic3005745" target="_blank" >http://dx.doi.org/10.1021/ic3005745</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/ic3005745" target="_blank" >10.1021/ic3005745</a>
Alternative languages
Result language
angličtina
Original language name
Combined theoretical and computational study of interstrand DNA guanine-guanine cross-linking by trans-[Pt(pyridine)2] derived from the photoactivated prodrug trans,trans,trans-[Pt(N3)2(OH)2(pyridine)2]
Original language description
Molecular modeling and extensive experimental studies were used to study DNA distortions induced by binding platinum(II)-containing fragments derived from cisplatin and a new class of photoactive platinum anticancer drugs. The major photoproduct of the novel platinum(IV) prodrug trans,trans,trans-[Pt(N3)2(OH)2(py)2] contains the trans-{Pt(py)2}2+ moiety. Using a tailored DNA sequence, experimental studies established the possibility of interstrand binding of trans-{Pt(py)2}2+ to guanine N7 positions oneach DNA strand. It was shown that such cross-links offer possibilities for specific protein-DNA interactions and suggest possible mechanisms to explain the high potency of this photoactivated complex.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
BO - Biophysics
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GAP301%2F10%2F0598" target="_blank" >GAP301/10/0598: Metallodrugs based on osmium, platinum and ruthenium complexes. From mechanistic studies to novel, more efficient chemotherapy of cancer</a><br>
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Inorganic Chemistry
ISSN
0020-1669
e-ISSN
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Volume of the periodical
51
Issue of the periodical within the volume
12
Country of publishing house
US - UNITED STATES
Number of pages
12
Pages from-to
6830-6841
UT code for WoS article
000305314500048
EID of the result in the Scopus database
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