Recognition of DNA/RNA bulges by antimicrobial and antitumor metallohelices
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F15%3A00457639" target="_blank" >RIV/68081707:_____/15:00457639 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1039/c5dt02018b" target="_blank" >http://dx.doi.org/10.1039/c5dt02018b</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1039/c5dt02018b" target="_blank" >10.1039/c5dt02018b</a>
Alternative languages
Result language
angličtina
Original language name
Recognition of DNA/RNA bulges by antimicrobial and antitumor metallohelices
Original language description
Bulged structures have been identified in nucleic acids and have been shown to be linked to biomolecular processes involved in numerous diseases. Thus, chemical agents with affinity for bulged nucleic acids are of general biological significance. Herein,the mechanism of specific recognition and stabilization of bulged DNA and RNA by helical bimetallic species was established through detailed molecular biophysics and biochemistry assays. These agents, known as 'flexicates', are potential mimetics of alpha-helical peptides in cancer treatment, exhibiting antimicrobial and antitumor effects. The flexicates have positive impacts on the thermal stability of DNA duplexes containing bulges, which means that the flexicates interact with the duplexes containing bulges, and that these interactions stabilize the secondary structures of these duplexes. Notably, the stabilising effect of the flexicates increases with the size of the bulge, the maximal stabilization is observed for the duplexes con
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
BO - Biophysics
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GAP205%2F11%2F0856" target="_blank" >GAP205/11/0856: Thermodynamics of DNA damaged by physical and chemical agents</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Dalton Transactions
ISSN
1477-9226
e-ISSN
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Volume of the periodical
44
Issue of the periodical within the volume
33
Country of publishing house
GB - UNITED KINGDOM
Number of pages
10
Pages from-to
14656-14665
UT code for WoS article
000359457600011
EID of the result in the Scopus database
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