Cationic Fe-II Triplex-Forming Metallohelices as DNA Bulge Binders
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F20%3A00536139" target="_blank" >RIV/68081707:_____/20:00536139 - isvavai.cz</a>
Result on the web
<a href="https://chemistry-europe.onlinelibrary.wiley.com/doi/epdf/10.1002/chem.202004060" target="_blank" >https://chemistry-europe.onlinelibrary.wiley.com/doi/epdf/10.1002/chem.202004060</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/chem.202004060" target="_blank" >10.1002/chem.202004060</a>
Alternative languages
Result language
angličtina
Original language name
Cationic Fe-II Triplex-Forming Metallohelices as DNA Bulge Binders
Original language description
Bulges are essential structural elements in nucleic acids. The detection and targeting of bulged DNA sequences are highly important. Small molecules capable of targeting DNA bulges have attracted considerable attention because they cannot only be used as reagents for bulge recognition, but also as potential therapeutic drugs. Herein, the interactions of DNA duplexes, containing bulges of various sizes and base compositions, with a series of Fe-II triplex-forming metallohelices are reported. The results obtained, with the aid of molecular biophysics methods, show that the investigated metallohelices prefer to bind to bulged DNA, rather than double-stranded DNA, and that their binding affinities towards bulges differ among individual metallohelices. Moreover, their binding affinities towards bulges strongly depend on the bulge size and the base composition of the bulge loop. The investigated metallohelices can enter eukaryotic cells and accumulate in the cell nucleus, allowing them to interact with nucleic acids. Hence, it is reasonable to suggest that the interaction of metallohelices with nucleic acid bulges might contribute to the mechanism of their biological activity.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10406 - Analytical chemistry
Result continuities
Project
<a href="/en/project/GA20-00735S" target="_blank" >GA20-00735S: Metallo-supramolecular helicates as DNA condensing agents and carriers for DNA delivery</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Chemistry - A European Journal
ISSN
0947-6539
e-ISSN
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Volume of the periodical
2020
Issue of the periodical within the volume
2020
Country of publishing house
DE - GERMANY
Number of pages
9
Pages from-to
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UT code for WoS article
000589586000001
EID of the result in the Scopus database
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