The crucial role of L-arginine in macrophage activation: What you need to know about it

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F15%3A00457642" target="_blank" >RIV/68081707:_____/15:00457642 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.lfs.2015.07.012" target="_blank" >http://dx.doi.org/10.1016/j.lfs.2015.07.012</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.lfs.2015.07.012" target="_blank" >10.1016/j.lfs.2015.07.012</a>

Result language
angličtina
Original language name
The crucial role of L-arginine in macrophage activation: What you need to know about it
Original language description
Nowadays, it is well recognized that amino acids are powerful molecules responsible for regulatory control over fundamental cellular processes. However, our understanding of the signaling cascades involved in amino acid sensing in organisms, as well as signal initiation, is largely limited. This is also the case of semi-essential amino acid L-arginine, which has multiple metabolic fates, and it is considered as one of the most versatile amino acids. Recently, some new and important facts have been published considering the role of L-arginine in the regulation of inflammatory processes in several human and mouse models, mediated also via the regulation of macrophage activation. Therefore, this mini review focuses on the actual summarization of information about (i) L-arginine bioavailability in organism, (ii) L-arginine-dependent regulation of nitric oxide synthase expression and nitric oxide production, and importantly (iii) its role in the activation of intracellular signaling pathway
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
BO - Biophysics
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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