The unique role of dietary L-arginine in the acceleration of peritoneal macrophage sensitivity to bacterial endotoxin

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F13%3A00060688" target="_blank" >RIV/00159816:_____/13:00060688 - isvavai.cz</a>
Alternative codes found
RIV/68081707:_____/13:00392737 RIV/00216305:26620/12:PU100939 RIV/00216224:14310/13:00081845
Result on the web
<a href="http://dx.doi.org/10.1007/s12026-012-8379-2" target="_blank" >http://dx.doi.org/10.1007/s12026-012-8379-2</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s12026-012-8379-2" target="_blank" >10.1007/s12026-012-8379-2</a>

Result language
angličtina
Original language name
The unique role of dietary L-arginine in the acceleration of peritoneal macrophage sensitivity to bacterial endotoxin
Original language description
It is known that cells and organisms can indirectly "sense" changes in l-arginine availability via changes in the activity of various metabolic pathways. However, the mechanism(s) by which genes can be directly regulated by l-arginine in mammalian cellshave not yet been elucidated. We investigated the effect of l-arginine in the in vivo model of peritoneal inflammation in mice and in vitro in RAW 264.7 macrophages. A detailed analysis of basic physiological functions and selected intracellular signaling cascades revealed that l-arginine is crucial for the acceleration of macrophage activation by bacterial lipopolysaccharide. l-arginine increased the production of reactive oxygen species, nitric oxide, release of Ca2+, as well as inducible nitric oxidesynthase expression. Interestingly, the effect of l-arginine on macrophage activation was dependent on the phosphorylation of mitogen-activated protein kinases and activity of phospholipase C. In RAW 264.7 cells, l-arginine was shown to
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FN - Epidemiology, infection diseases and clinical immunology
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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