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Asymmetric dimethylarginine regulates the lipopolysaccharide-induced nitric oxide production in macrophages by suppressing the activation of NF-kappaB and iNOS expression

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F13%3A00394792" target="_blank" >RIV/68081707:_____/13:00394792 - isvavai.cz</a>

  • Result on the web

    <a href="http://dx.doi.org/10.1016/j.ejphar.2013.05.001" target="_blank" >http://dx.doi.org/10.1016/j.ejphar.2013.05.001</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.ejphar.2013.05.001" target="_blank" >10.1016/j.ejphar.2013.05.001</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Asymmetric dimethylarginine regulates the lipopolysaccharide-induced nitric oxide production in macrophages by suppressing the activation of NF-kappaB and iNOS expression

  • Original language description

    Two major effector systems are frequently implicated in the immune and endothelial cell alternations associated with inflammation. They include the enhanced production of reactive oxygen species and diminished bioavailability of nitric oxide (NO). Importantly, these processes can be regulated by endogenously produced methylarginines, inhibitors for NO derived from macrophages and endothelial cells. Therefore, the aim of this study was to show the potential pharmacological intervention of methylarginines(N-G-methyl-L-arginine, L-NMMA; N-G, N-G'-dimethyl-L-arginine-symmetric dimethylarginine, SDMA; and N-G, N-G-dimethyl-L-arginine-asymmetric dimethylarginine, ADMA) in activation of murine peritoneal (RAW 264.7) and alveolar (MHS) macrophages with lipopolysaccharide from Gram-negative bacteria (LPS).

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    BO - Biophysics

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/GP13-40882P" target="_blank" >GP13-40882P: Role of L-arginine, methylarginines and their metabolism in regulation of endothelial homeostasis</a><br>

  • Continuities

    Z - Vyzkumny zamer (s odkazem do CEZ)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2013

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    European Journal of Pharmacology

  • ISSN

    0014-2999

  • e-ISSN

  • Volume of the periodical

    713

  • Issue of the periodical within the volume

    1-3

  • Country of publishing house

    NL - THE KINGDOM OF THE NETHERLANDS

  • Number of pages

    10

  • Pages from-to

    68-77

  • UT code for WoS article

    000320903900011

  • EID of the result in the Scopus database