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Conferring resistance to geminiviruses with the CRISPR-Cas prokaryotic immune system

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F15%3A00472038" target="_blank" >RIV/68081707:_____/15:00472038 - isvavai.cz</a>

  • Result on the web

    <a href="http://dx.doi.org/10.1038/NPLANTS.2015.145" target="_blank" >http://dx.doi.org/10.1038/NPLANTS.2015.145</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1038/NPLANTS.2015.145" target="_blank" >10.1038/NPLANTS.2015.145</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Conferring resistance to geminiviruses with the CRISPR-Cas prokaryotic immune system

  • Original language description

    To reduce crop losses due to geminivirus infection, we targeted the bean yellow dwarf virus (BeYDV) genome for destruction with the CRISPR-Cas (clustered, regularly interspaced short palindromic repeats-CRISPR-associated proteins) system. Transient assays using BeYDV-based replicons revealed that CRISPR-Cas reagents introduced mutations within the viral genome and reduced virus copy number. Transgenic plants expressing CRISPR-Cas reagents and challenged with BeYDV had reduced virus load and symptoms, thereby demonstrating a novel strategy for engineering resistance to geminiviruses.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    BO - Biophysics

  • OECD FORD branch

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2015

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Nature Plants

  • ISSN

    2055-026X

  • e-ISSN

  • Volume of the periodical

    1

  • Issue of the periodical within the volume

    10

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    15

  • Pages from-to

  • UT code for WoS article

    000364414200002

  • EID of the result in the Scopus database