Pure non-dioxin-like PCB congeners suppress induction of AhR-dependent endpoints in rat liver cells
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F16%3A00456569" target="_blank" >RIV/68081707:_____/16:00456569 - isvavai.cz</a>
Alternative codes found
RIV/00027162:_____/16:N0000045
Result on the web
<a href="http://dx.doi.org/10.1007/s11356-015-4819-6" target="_blank" >http://dx.doi.org/10.1007/s11356-015-4819-6</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s11356-015-4819-6" target="_blank" >10.1007/s11356-015-4819-6</a>
Alternative languages
Result language
angličtina
Original language name
Pure non-dioxin-like PCB congeners suppress induction of AhR-dependent endpoints in rat liver cells
Original language description
The relative potencies of non-ortho-substituted coplanar polychlorinated biphenyl (PCB) congeners to activate the aryl hydrocarbon receptor (AhR) and to cause the AhR-dependent toxic events are essential for their risk assessment. Since some studies suggested that abundant non-dioxin-like PCB congeners (NDL-PCBs) may alter the AhR activation by PCB mixtures and possibly cause non-additive effects, we evaluated potential suppressive effects of NDL-PCBs on AhR activation, using a series of 24 highly purified NDL-PCBs. We investigated their impact on the model AhR agonist-induced luciferase reporter gene expression in rat hepatoma cells and on induction of CYP1A1/1B1 mRNAs and deregulation of AhR-dependent cell proliferation in rat liver epithelial cells.PCBs 128, 138, and 170 significantly suppressed AhR activation (with IC50 values from 1.4 to 5.6 mu M), followed by PCBs 28, 47, 52, and 180; additionally, PCBs 122, 153, and 168 showed low but still significant potency to reduce lucifer
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
BO - Biophysics
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GBP503%2F12%2FG147" target="_blank" >GBP503/12/G147: Centre for studies on toxicity of nanoparticles</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Environmental Science and Pollution Research
ISSN
0944-1344
e-ISSN
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Volume of the periodical
23
Issue of the periodical within the volume
3
Country of publishing house
DE - GERMANY
Number of pages
9
Pages from-to
2099-2107
UT code for WoS article
000368376800014
EID of the result in the Scopus database
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