Four Ways to Oligonucleotides Without Phosphoimidazolides
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F16%3A00456657" target="_blank" >RIV/68081707:_____/16:00456657 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14740/16:00090499
Result on the web
<a href="http://dx.doi.org/10.1007/s00239-015-9709-5" target="_blank" >http://dx.doi.org/10.1007/s00239-015-9709-5</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00239-015-9709-5" target="_blank" >10.1007/s00239-015-9709-5</a>
Alternative languages
Result language
angličtina
Original language name
Four Ways to Oligonucleotides Without Phosphoimidazolides
Original language description
Emergence of the very first RNA or RNA-like oligomers from simple nucleotide precursors is one of the most intriguing questions of the origin of life research. In the current paper, we analyse the mechanism of four non-enzymatic template-free scenarios suggested for the oligomerization of chemically non-modified cyclic and acyclic nucleotides in the literature. We show that amines may have a twofold role in these syntheses: due to their high affinity to bind protons they may activate the phosphorus of the phosphate group via proton transfer reactions, or indirectly they may serve as charge compensating species and influence the self-assembling of nucleotides to supramolecular architectures compatible with the oligomerization reactions. Effect of cations and pH on the reactions is also discussed.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
BO - Biophysics
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Molecular Evolution
ISSN
0022-2844
e-ISSN
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Volume of the periodical
82
Issue of the periodical within the volume
1
Country of publishing house
US - UNITED STATES
Number of pages
6
Pages from-to
5-10
UT code for WoS article
000368026600002
EID of the result in the Scopus database
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