Constant Current Chronopotentiometry as a Method for Detection of Singlet Oxygen Protein Damage

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F16%3A00506684" target="_blank" >RIV/68081707:_____/16:00506684 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Constant Current Chronopotentiometry as a Method for Detection of Singlet Oxygen Protein Damage
Original language description
Proteins are one of the major targets for oxidative damage in the cell.Indirect non-radical oxidation of the protein via formation and subsequent reaction with single oxygen (O-1(2))is one of the major processes.In this work we studied the single oxygen(O-1(2))-mediated oxidation of bovine serum albumin (BSA) by constant current chronopotentiometry in combination with mercury electrode.Our chronopotentiometric data show that photo-oxidized BSA was more susceptible to the electric field-induced denaturation than non-oxidized native BSA. Our method utilizing intrinsic electrochemical signal of proteins provides a sensitive detection methods for minor damages in various proteins.
Czech name
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Czech description
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Project
<a href="/en/project/GA13-00956S" target="_blank" >GA13-00956S: Emerging roles for the proteins of Anterior Gradient family in cancer development</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection
XXXVI. Moderní elektrochemické metody. Sborník přednášek
ISBN
978-80-905221-4-5
ISSN
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e-ISSN
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Number of pages
3
Pages from-to
"Č. 2016 (2016)"
Publisher name
Best servis
Place of publication
Ústí nad Labem
Event location
Jetřichovice
Event date
May 23, 2016
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
000389898200037

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