Function of heterochromatin protein 1 during DNA repair

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F17%3A00476428" target="_blank" >RIV/68081707:_____/17:00476428 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1007/s00709-017-1090-3" target="_blank" >http://dx.doi.org/10.1007/s00709-017-1090-3</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00709-017-1090-3" target="_blank" >10.1007/s00709-017-1090-3</a>

Result language

angličtina

Original language name

Function of heterochromatin protein 1 during DNA repair

Original language description

This review focuses on the function of heterochromatin protein HP1 in response to DNA damage. We specifically outline the regulatory mechanisms in which HP1 and its interacting partners are involved. HP1 protein subtypes (HP1 alpha, HP1 beta, and HP1 gamma) are the main components of constitutive heterochromatin, and HP1 alpha and HP1 beta in particular are responsible for heterochromatin maintenance. The recruitment of these proteins to DNA lesions is also important from the perspective of proper DNA repair mechanisms. For example, HP1 alpha is necessary for the binding of the main DNA damage-related protein 53BP1 at DNA repair foci, which are positive not only for the HP1 alpha protein but also for the RAD51 protein, a component of DNA repair machinery. The HP1 beta protein also appears in monomeric form in DNA lesions together with the evolutionarily well-conserved protein called proliferating cell nuclear antigen (PCNA). The role of HP1 in DNA lesions is also mediated via the Kap1 transcription repressor. Taken together, these results indicate that the function of HP1 after DNA injury depends strongly on the kinetics of other DNA repair-related factors and their post-translational modifications, such as the phosphorylation of Kap-1.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10601 - Cell biology

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Protoplasma

ISSN

0033-183X

e-ISSN

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Volume of the periodical

254

Issue of the periodical within the volume

3

Country of publishing house

AT - AUSTRIA

Number of pages

17

Pages from-to

1233-1240

UT code for WoS article

000399037400010

EID of the result in the Scopus database

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